活動名稱
諾貝爾2011年醫學獎得主 Dr. Bruce A. Beutler演講
場次名稱
諾貝爾2011年醫學獎得主 Dr. Bruce A. Beutler演講
場次內容
How Endogenous Retroviruses Have Become an Integral Component of the Host Immune Response.
Abstract: (完整abstract請見附件)
The antibody response to type 2 T-cell independent (TI-2) antigens is important for defense against infections. Initiated by B cell receptor (BCR) crosslinking in the absence of T cell help, there has been no suggestion of a requirement for innate immune signaling. However, we have discovered that cytosolic RNA and DNA sensing pathways operate within B cells to permit optimal induction of the TI-2 response. Cross-linking of the BCR by TI-2 antigens leads to upregulation of numerous endogenous retrovirus (ERV) RNAs in B cells in a Btk and NF-κB dependent manner. These RNAs are directly detected via a MAVS-dependent RNA sensing pathway, which activates NF-κB, or reverse transcribed and indirectly detected via the cGAS-cGAMP-STING pathway, triggering a second, sustained wave of signaling that promotes specific IgM production. Deficiency of both MAVS and cGAS
授課人
Dr. Bruce A. Beutler
活動地點
臺大校總區圖書館B1國際會議廳
場次時間
2015-02-09 10:00:00 ~ 11:30:00
報名時間
2015-01-15 12:00:00 ~ 2015-02-08 23:59:00
承辦單位
國際事務處國際合作組
承辦人
鄧伊倫; 02-33662007#221; ilunteng@ntu.edu.tw
報名類型
自由報名
參加對象
不限
其他限制條件
無
報名費
免費
人數名額
200 人
尚餘名額
0 人
用餐
不提供
是否提供公務人員學習時數
否
研習總時數
0 小時
學習類別
實體學習
學位學分
無
期別
1
活動縣市
10.臺北市
附件
備註
無
