活動名稱
國立台灣大學統計教學中心統計學術演講
場次名稱
統計學術演講
場次內容
講題:Asymptotic bioequivalence tests based on generalized gamma mixed-effects model
講者:陳玉英教授
時間:2013年5月3日星期五 下午 3:00 ~ 5:00
地點:博雅教學館408教室
費用:免費
名額:40位
摘要:
In the pharmacokinetic (PK) study under a 2x2 crossover design that involves both the test and reference drugs, we propose a mixed-effects model for the drug concentration-time profiles obtained from subjects who receive different drugs at different time periods. In the proposed model, the drug concentrations repeatedly measured from the same subject at different time points are distributed according to a multivariate generalized gamma distribution and the drug concentration-time profiles are described by a compartmental PK model with between-subject and within-subject variations. We then suggest a bioequivalence test based on the estimated bioavailability parameters in the proposed mixed-effects model. The results of a Monte Carlo study further show that the proposed model-based bioequivalence test is not only better on maintaining
授課人
陳玉英
活動地點
博雅教學館408教室
場次時間
2013-05-03 15:00:00 ~ 17:00:00
報名時間
2013-04-18 10:00:00 ~ 2013-05-02 12:00:00
承辦單位
統計教學中心
承辦人
張仲凱; 02-33661481#214; sec@statedu.ntu.edu.tw
報名類型
自由報名
參加對象
不限
其他限制條件
無
報名費
免費
人數名額
40 人
尚餘名額
26 人
用餐
不提供
是否提供公務人員學習時數
是
研習總時數
2 小時
學習類別
實體學習
學位學分
無
期別
1
活動縣市
10.臺北市
附件
無
備註
無