Focused Ultrasound Induced Blood-Brain Barrier Opening and Its Therapeutic Application
Hao-Li Liu 劉浩澧
Department of Electrcial Enginerring, Chang Gung University, Taoyuan, Taiwan.
Focused ultrasound (FUS) technology, which appears half century ago, has got more and more attention on its clinical therapeutic potential in recent years. Recently, FUS with the presence of microbubbles has been noticed to be capable of locally and reversibly disrupting blood-brain barrier (BBB) without causing neuronal damage and proof its potential in the delivery of macromolecules into CNS, including those therapeutic agents for CNS therapy which may not naturally cross the barrier into brain, and brings bright hopes for noninvasive brain drug delivery for treating brain cancers or neurodegenerative diseases. Since real-time image guidance is necessary, detecting and monitoring local drug release is one key step and a critical role to the success of..